As Crew-10 prepares to depart the International Space Station after a four-month mission, two women at the center of the journey—Commander Anne McClain and Pilot Nichole Ayers—took time to reflect on their experience in orbit and the deeper meaning behind their work in space.

During the livestream, McLain and Ayers discussed just how much it meant to them to be able to go on such a length expedition, and how important it is to pass on their command to Expedition 73’s new leader.

McClain, a decorated U.S. Army colonel and NASA astronaut, opened the remarks with a message of unity and hope. “We want this mission, our mission, to be a reminder of what people can do when we work together, when we explore together.” She noted that the political climate 40 years ago, when the ISS was first conceived, was similar to what it is now. But that the ISS shows the power of coming together as humans. “This mission is a snapshot in time today, our mission.” she said.

Her co-pilot, U.S. Air Force Major Nichole Ayers, followed with her own reflections, emphasizing gratitude for the teams on the ground who made the mission possible.

Both women expressed thanks to their families and friends back on Earth. “We wouldn’t be here without your support,” Ayers said. “None of us would be.”

The significance of their presence aboard the ISS goes beyond operational excellence and scientific discovers. McClain and Ayers represent the next generation of women who are going to head into the unknown to solve the problems of tomorrow with diplomacy and human endurance.

As the ISS prepares for the next chapter under new leadership, McClain and Ayers are more than astronauts who completed a series of objectives. They leave a legacy of excellence, resilience, and hope for what humanity can achieve—together, and among the stars.